Permeability

• Deep penetration of the skin in the form of Nanogel
• Size: <100 nm
• Deep penetration increases the moisturizing effect of powerful skin

Delivery

• Transfer more stabilized vitamin C into the skin
• Collect the active ingredients and deliver them to the skin.
• Sustained efficacy through sustained release

Safety

• Safe materials that do not use crosslinking agents at all
• Safe materials without toxicity and skin irritation (GLP test)

Stability

• Stable material for light and heat through the conjugation of hyaluronic acid and vitamins

Efficacy

• Whitening, improving wrinkles
• Anti-inflammation, Antioxidation
• Moisturizing,  wound healing

Active oxygen species

• Recently, due to changes in living environment and eating habits, interest in active oxygen, which is involved in various adult diseases and aging, is increasing.. These ROS interact with cellular components such as lipids, proteins, carbohydrates, and DNA to alter oxidative damage and enzyme activity, causing various diseases such as heart disease, ischemia, arteriosclerosis, and cancer as well as brain diseases such as stroke and Parkinson’s disease. It is reported that it not only damages biological tissue but also promotes aging.

Solution
(Antioxidant)

• The need for the development of antioxidants that can regulate reactive oxygen species in vivo has been emphasized, and traditionally well-known antioxidants include vitamin C and E, as well as polyphenol compounds.

Features

• It is a linear molecule found in human sperm and grape fruit, and is involved in cell growth, maturation, anti-aging and antioxidant processes.Spermidine plays an important role in blocking various environmental stresses. Furthermore, it has been reported that spermidine has a protective effect against toxicity and deficiency of heavy metals as well as oxidative stress.

Efficacy

• Useful Biomaterials for the development of functional cosmetics, pharmaceuticals, quasi-drugs and medical devices, such as wrinkle improvement, wound healing, inflammation improvement, and atopic dermatitis improvement

Permeability

• Deep penetration of the skin in the form of Nanogel
• Size: 100 nm to 150 nm
• Deep penetration increases skin improvement effects such as strong anti-aging

Delivery

• The hydrophilic material and the system which encapsulates the lipophilic material, and it is used in the cosmetics field as nutraceutical and water carrier, and controls the settling velocity

Safety

• The most skin-friendly structure with less irritation and no biological membrane

Stability

• Structurally, bilayer microinclusions of phospholipids similar to Skin Bio lipid membranes are present in a bilayer sphere due to their hydrophobic and hydrophilic parts.

Efficacy

• Wrinkle improvement, anti-aging
• Anti-inflammatory, antioxidative.
• Moisturizing

Background

• Materials that promote cell growth are greatly beneficial for wound healing and tissue regeneration, and commercially available wound healing ointments include anti-inflammatory agents, antibiotics, and cell growth promoters as key ingredients

Medications

• The compound prevents the cell from being damaged by cytotoxic substances and selectively promotes the growth of normal cells, not cancer cells
• Wound healing, tissue regeneration and anti-aging

Cosmetics

• Aging prevention, wrinkle improvement or skin elasticity enhancement effect

Existing LNP problems

• Stability for storage and efficiency of antigen expression of delivered mRNA should be improved.
• Existing second-generation LNP technology is not developed for human vaccines, so it has little immunity induction
• Helper lipids and PEG lipids, including the ionizing lipids that make up the LNP formulation, are injected into the body in greater quantities than mRNA in fact; these substances can enter the body and cause toxicity or side effects.

Innovative Idea
&
The Candidate

• The excavated PEG lipid candidate is subjected to optimization process based on various uses and possibilities, and it is being promoted to avoid existing patents through this method
• Recently, an international paper has been published that autophagy in T cells is maintained by one of our candidate substances and is related to function and vaccine response (see article)
• LNP substance that activates physiologically active substances, low tolerance and toxicity, and expected to have a combined effect of immune enhancement (Immunoinducible)
• Anti-inflammation of the LNP component itself and anti-aging (activation) of immune cells are expected (see article)
• It is possible to manufacture various LNPs through the construction of LNP platform using bioactive substances
• Possibility of avoiding in vivo nuclease by activation of LNP bioactive substance
• Simplify production and reduce production costs compared to existing LNP production
• Other: Antioxidant, antiallergic, detoxifying, immune-inducing, aging T cell activation, hormonal, antibacterial, antiviral. It has functions such as acetylation and phosphorylation of proteins, activation of enzymes, stabilization of cell membranes, etc.